Inhalation Delivery of Therapeutic Peptides and Proteins (1997, Hardcover)

This exhaustive reference-the first book of its kind to describe in detail the functionality of the human respiratory tract and its impact on both local and systemic delivery of biotherapeutic and macromolecular drug systems-offers comprehensive analyses of peptide and protein drug delivery through the lung. Summarizes over 130 patents granted worldwide on alternative systems for pulmonary delivery of therapeutic drugs-especially peptides and proteins! Examining macromolecular drug delivery as an efficient, patient-friendly, and cost-effective method of treatment, Inhalation Delivery of Therapeutic Peptides and Proteins discusses · airway physiology and biomechanics · the pharmaceutical concerns associated with the respiratory tract as a viable port of drug entry to the body · key peptide drugs under development and in use to treat local lung disease, including cyclosporines, interferons, antitrypsins, protease inhibitors, and deoxyribonucleases · the systemic delivery of peptide and protein drugs using fine-particle technology · gene therapy employing gene delivery through the airways · new developments in pulmonary delivery technologies emphasizing inhaled peptide and protein drugs · guidelines for the successful introduction of peptide inhalation aerosol products into the marketplace · and much more!